AbstractsMedical & Health Science


by Dereje Tekalegne

Institution: Addis Ababa University
Year: 2015
Keywords: UTI; fistula patients; Hamlin Fistula Hospital; Addis Ababa; Ethiopia.
Posted: 02/05/2017
Record ID: 2133590
Full text PDF: http://etd.aau.edu.et/dspace/handle/123456789/8041


Background: Urinary Tract Infection (UTI) causes a serious health problem and affects millions of people worldwide. Patients with obstetric fistula usually suffer from incontinence of urine and stool, which can predispose them to frequent infections of the urinary tract. Objectives: This study was undertaken to determine the etiologic agents, drug resistance pattern of the isolates and associated risk factor for urinary tract infection among fistula patients in Addis Ababa fistula hospital, Ethiopia. Methods: Across sectional study was conducted from February to May 2015 at HamlinFistula Hospital, Addis Ababa, Ethiopia. Socio-demographic characteristics and other UTI related risk factors were collected from study participants using structured questionnaires. The mid-stream urine was collected and cultured on Cysteine lactose electrolyte deficient agar, blood agar and MacConkey agar. Antimicrobial susceptibility was done by using disc diffusion method and interpreted according to Clinical and Laboratory Standards Institute (CLSI). Data was entered and analyzed by using SPSS version 20. Results: Out of 210 fistula patients investigated 169(80.5%) of the patient were younger than 25 years. Significant bacteriuria was observed in 122/210(58.1%) and 68(55.7%) of the isolates were from symptomatic cases. E.coli 65(53.7%) were the most common bacterial pathogen isolated followed by Proteus spp. 31(25.4%). Statistical Significant difference was observed with history of previous UTI (P= 0.031) and history of catheterization (P=0.001).Gram negative bacteria isolates showed high level of resistance (>50%) to gentamicin and ciprofloxacin, while all gram positive bacteria isolated were showed low level of resistance (20-40%)to most of antibiotic tested. Conclusion and Recommendation: The overall prevalence of urinary tract infection among fistula patient is 58.1%. This study showed that the predominant pathogen of UTI were E.colifollowed by Proteus spp. It also showed that amoxicillin-clavulanic acid was a drug of choice for urinary tract bacterial pathogens. Based on the finding of the present study routine screening of all fistula patients for UTI and performing urine culture and antimicrobial susceptibility testing is recommended. Key words: UTI, fistula patients, Hamlin Fistula Hospital, Addis Ababa, Ethiopia. Advisors/Committee Members: Yimtubezenash Woldeamanuel (PHD) (advisor).