AbstractsBiology & Animal Science

Development of Novel Magnesium Phosphate Bone Cement

by Niloufar Rostami

Institution: University of Toledo
Department: Bioengineering
Degree: MS
Year: 2015
Keywords: Biomedical Engineering
Record ID: 2061957
Full text PDF: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1418326907


This study aims to develop a novel magnesium phosphate based injectable cement for orthopedic applications. Magnesium phosphate cements (MPC) provide more favorable clinical performances including shorter setting time, and higher resorption rates and strength, as compared to the commonly used calcium phosphate cements. These features make magnesium cements great potential candidates for orthopedic and dental applications. In this study, the magnesium phosphate cement is prepared using a microwave assisted precipitation process. An experimental study is conducted to evaluate developed phases, setting times, injectability, and mechanical strength of the prepared cement. X-ray diffraction and SEM techniques are used to characterize the structure of powders with or without physiological conditions. Physiological conditions are simulated by soaking MPC pellets in Simulated Body Fluid (SBF). To determine the cytotoxicity effects of the as-synthesized magnesium phosphate cements, the mammalian preosteoblast cells are cultured on the MPC samples and the biocompatibility of the materials is confirmed.