AbstractsMedical & Health Science

The effects of N-acetylcysteine infusion on performance, glutathione and ion regulation during voluntary exercise in humans

by Ivan Medved

Institution: Victoria University of Technology
Department: School of Human Movement, Recreation and Performance
Year: 2005
Keywords: 1116 Medical Physiology; School of Sport and Exercise Science; 1106 Human Movement and Sports Science
Record ID: 1049932
Full text PDF: http://vuir.vu.edu.au/15641/


The production of reactive oxygen species in skeletal muscle has been linked with muscle fatigue. Infusion of the antioxidant compound 7V-acetylcysteine (NAC) reduced fatigability in electrically evoked human muscle contractions, but numerous adverse reactions were reported. No studies have investigated NAC infusion effects during voluntary exercise in humans. This thesis investigated whether an NAC infusion protocol that was modified to minimise these adverse reactions, would augment time to fatigue, enhance glutathione availability and enhance potassium (K+) regulation during voluntary fatiguing exercise.