The development of peptide-based inhibitors of the low affinity Fc receptor, Fc [gamma] RIIa

by Angela Cendron

Institution: Victoria University of Technology
Department: School of Molecular Sciences
Year: 2005
Keywords: 1107 Immunology; School of Engineering and Science
Record ID: 1032253
Full text PDF: http://vuir.vu.edu.au/15580/


FcyRIIa is an activatory receptor and contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain, involved in the initiation of signalling events. There is now strong evidence from transgenic mouse models and human genetic susceptibility studies that implicate FcyRIIa in a number of immune diseases including, rheumatoid arthritis, systemic lupus erythematosus (SLE) and immune thrombocytopenia purpura (ITP). FcyRHa is therefore a promising target for the development of therapeutics to treat these diseases.