Mutations in regulators of the epigenome and their effects on the DNA methylome

by Farga Jessica La

Institution: Humboldt State University
Year: 2015
Keywords: Concussion; Inverted pendulum mechanics; Cost of transport; Biomechanics; Walking energetics; Dynamic stability; Gait; Executive function
Posted: 02/05/2017
Record ID: 2123479
Full text PDF: http://hdl.handle.net/10211.3/150428


A concussion is a type of traumatic brain injury that results in an overall decrease in executive function. Previous literature has reported that significant reductions in balance occur in the concussed during the acute phases of recovery. However, it is unknown whether changes in stability associated with concussive injury result in changes to conservation of mechanical energy and metabolic cost during walking. The purpose of this study was to determine the effect of concussion the mechanics and energetics of walking. I hypothesized that within the first 2-7 days following injury, individuals who have sustained a concussion would exhibit a greater the metabolic cost of walking and impaired inverted pendulum mechanics. To address this problem, I collected neurocognitive, metabolic, and kinematic data on 14 normal subjects (5 female and 9 male) and 10 concussed subjects (5 female and 5 male). I found no significant differences in the metabolic cost of transport due to concussive status across the speeds of 0.75 m s-1, 1.25 m s-1, and 1.50 m s-1 (p<.05). Advisors/Committee Members: Ortega, Justus.