AbstractsBiology & Animal Science

Synthesis of a 6-substituted Uridine Derivative

by Yiyu Lin

Institution: California State University – East Bay
Degree: MSin Chemistry
Year: 2015
Keywords: Uridine
Record ID: 2061352
Full text PDF: http://hdl.handle.net/10211.3/137877


Orotidine 5???- monophosphate decarboxylase (ODCase), an enzyme known to catalyze the decarboxylation of orotidine 5???-monophosphate (OMP) to uridine 5???-monophosphate (UMP), is a potentially useful target for developing drugs. Many uridine derivatives have been reported as ODCase inhibitors. We were interested to discover if different groups can be placed on the C6 position of uridine using a dianion quenched with electrophilic reagents. We want to place a hydroxamic acid group at the C6 position of uridine because it would resemble the carboxylic acid group of orotidine, and the 5???-monophosphate derivative of it might show potent inhibition of ODCase. Here, we prepared a new compound which may lead to a new manner of inhibiting the enzyme orotidine 5???-monophosphate decarboxylase.