U.S. military and civilian vessels are critically vulnerable to asymmetric threats in littoral environments. Common asymmetric weapons such as Anti-Ship Cruise Missiles (ASCM), Low Slow Flying (LSF) aircraft and Fast Attack Craft (FAC) / Fast Inshore Attack Craft (FIAC) threaten U.S. strategic goals and can produce unacceptable losses of men and material. The SEA-18B team presents an operational concept for a family of Unmanned Surface Vessels USV) capable of defending ships from asymmetric swarm attacks. This USV, the Tailorable Remote Unmanned Combat Craft (TRUCC), can operate in concert with the next generation of capital surface vessels to combat this critical threat with maximum efficiency. Critical performance criteria of the TRUCC family were determined through agent-based simulation of a Straits of Hormuz Design Reference Mission. Additional models addressed ship synthesis and operational availability. A Technology and Capability Roadmap outlines areas of interest for investment and development of the next-generation USV. Interim technology and capability milestones in the Roadmap facilitate incremental USV operational capabilities for missions such as logistics, decoy operations and Mine Warfare. The TRUCC operational concept fills a critical vulnerability gap. Its employment will reduce combat risk to our most valuable maritime assets: our ships and our Sailors.