AbstractsChemistry

Amino acid-derived Lewis basic catalysts for asymmetric allylation of aldehydes and silylation of alcohols

by Yu Zhao




Institution: Boston College
Department:
Year: 2008
Keywords: catalytic asymmetric reaction; Lewis base; combinatorial approach
Record ID: 1837809
Full text PDF: http://hdl.handle.net/2345/357


Abstract

Chapter 1. Review of concept and methodology development for asymmetric allylation of carbonyls and imines. Chapter 2. Description of the catalytic asymmetric addition of allyltrichlorosilane to aldehydes catalyzed by a proline-based N-oxide catalyst. Chapter 3. Introduction of the first catalytic asymmetric silylation of alcohols for desymmetrization of meso-diols. Chapter 4. Presentation of asymmetric silylation for synthesis of chiral syn-1,2-diols by kinetic resolution or divergent reaction on a racemic mixture.