Amino acid-derived Lewis basic catalysts for asymmetric allylation of aldehydes and silylation of alcohols

by Yu Zhao

Institution: Boston College
Year: 2008
Keywords: catalytic asymmetric reaction; Lewis base; combinatorial approach
Record ID: 1837809
Full text PDF: http://hdl.handle.net/2345/357


Chapter 1. Review of concept and methodology development for asymmetric allylation of carbonyls and imines. Chapter 2. Description of the catalytic asymmetric addition of allyltrichlorosilane to aldehydes catalyzed by a proline-based N-oxide catalyst. Chapter 3. Introduction of the first catalytic asymmetric silylation of alcohols for desymmetrization of meso-diols. Chapter 4. Presentation of asymmetric silylation for synthesis of chiral syn-1,2-diols by kinetic resolution or divergent reaction on a racemic mixture.