The conversion of carotene to vitamin A in vitro.
Institution: | McGill University |
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Department: | Department of Agricultural Chemistry. |
Degree: | MS. |
Year: | 1947 |
Keywords: | Agricultural Chemistry. |
Record ID: | 1580067 |
Full text PDF: | http://digitool.library.mcgill.ca/thesisfile125503.pdf |
[...] Ozonolysls of carotene results in the formation of much larger fragments, and as in other oxidations geronic acid is formed. This acid is also obtained from the ozonolysls of vitamin A, Karrer (30). The mode of attack by ozone appears to be the primary formation of a heterocyclic five membered ring, at one of the double bonds, resembling a peroxide and epioxide. Recently, Hunter and Williams (28) have succeeded in converting carotene to vitamin A aldehyde by the carefully controlled oxidation with hydrogen peroxide, and subsequently converting this to the alcohol by reducing it with aluminium isopropoxide. Their yield (0.5 per cent) would not appear to justify their assumption that two molecules of vitamin A aldehyde are formed from one molecule of carotene.