AbstractsBiology & Animal Science

The absorption and oxidation of phenothiazine in the sheep.

by Robert Peter. Harpur




Institution: McGill University
Department: Department of Biochemistry.
Degree: MS.
Year: 1947
Keywords: Biochemistry.
Record ID: 1575739
Full text PDF: http://digitool.library.mcgill.ca/thesisfile125516.pdf


Abstract

Phenothiazine (thiodiphenylamine) is one of the most efficient drugs yet discovered for the removal of intestinal worms. It has a low toxicity for the sheep and has proved of great commercial value in the production of wool and mutton. The potential consumption of Australia and New Zealand was estimated by Gordon(63) in 1941, to be 1500 tons per year and the present day consumption on the North American continent is enormous. The value of any anthelmintic must be appraised in terms of the benefit derived by the host from the prevention of parasitic infestation. For instance, no one has shown that adult tapeworms are pathogenic and a drug which removes tapeworms, while of scientific interest, is commercially unimportant. However, many nematode species have been shown to have a harmful effect upon various hosts and a large number of these are removed by phenothiazine.[...]