Nucleolar characteristics in purkinje cells of the mouse during postnatal differentiation.
Institution: | McGill University |
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Department: | Department of Anatomy. |
Degree: | Doctor of Philosphy. |
Year: | 1965 |
Keywords: | Anatomy. |
Record ID: | 1568549 |
Full text PDF: | http://digitool.library.mcgill.ca/thesisfile118187.pdf |
The nucleoli of differentiating cells have long attracted the interest of investigators because of their variahility in number, volume and cytochemical features. Such variations have commonly been related to the physiochemical and cytochemical organization of the nucleolus. Specifically, the nucleolus has been considered an organelle of extreme plasticity, consisting of an apparently homogeneous ground substance (nucleolar matrix) which occasionally contains one or more vesicles (intranucleolar vacuoles or nucleolini). Relevant cytochemical and biochemical studies have indicated that these structural phases are composed of acid and basic proteins and RNA in the form of ribonucleoproteins. In brief, the classical concept of nucleolar structure recognized two intranucleolar structural phases – nucleolar matrix and intranucleolar vacuoles – composed of nucleolar ribonucleoproteins (reviews, Montgomery, 1898; Oates, 1942; Vincent, 1955; Stich, 1956; Hertl, 1957; Swift, 1959; Sirlin, 1962; Busch et al, 1963). [...]