AbstractsMedical & Health Science

The determination of histamine in blood and tissues under various conditions.

by Bram. Rose




Institution: McGill University
Department: Department of Experimental Medicine.
Degree: MS.
Year: 1937
Keywords: Experimental Medicine.
Record ID: 1565383
Full text PDF: http://digitool.library.mcgill.ca/thesisfile132239.pdf


Abstract

1. The histamine content of the normal and adrenalectomised male rat is lower than that of the female.2. Evidence is presented to show that there is an increase in the histamine content of the portal blood of the adrenalectomised rat after injury tothe gastro-intestinal tract, which appears within two minutes and disappears after five minutes.3. There is an increase in the histamine content of lung and lymphatic tissue in the normal rat which has been subjected to the action of muscularexercise, and surgical trauma.4. There is a decrease in the histamine content of the lung tissue and an increase of the histamine content of the lymphatic tissue in theadrenalectomised animal after surgical trauma and the intraperitoneal injection of histamine. This change is modified by the action of Cortin.