AbstractsBiology & Animal Science

Structural modification of normal metabolites has often led to compounds which no longer function normally but which interfere with the metabolism of the normal compound. A classical example of this phenomenon is the finding by Quastel and Wooldridge that malonate resembles succinic acid closely enough to inhibit succinic dehydrogenase. A glance through the recent treatise "Metabolic Inhibitors" (1) Will, convince the most skeptical reader of the importance of this approach in elucidating metabolic processes as well as in the field of chemotherapy. [...]