AbstractsMedical & Health Science

In spite of the early and brilliant observations of clinical pathologists, notably Rokitansky, who first called attention to the association of brain damage and pathological changes in the stomach, suggesting a neurogenic basis for ulcer formation, this concept was for many decades overshadowed by the views of Virchow and his followers who held that peptic ulcer was essentially a local disease. Although the neurogenic concept was later supported by both experimental and clinical studies, it was not until the publication of Gushing*s Balfour Lecture, relating peptic ulcer to disturbances in the interbrain, that the interest in this aspect of ulcer formation was revived.[...]