AbstractsBiology & Animal Science
The total synthesis of (-)-ent-Anhydromyriocin 1,2 : a thesis
| Institution: | McGill University |
|---|---|
| Department: | Department of Chemistry |
| Degree: | PhD |
| Year: | 1980 |
| Keywords: | Myriocin.; Thermozymocidin.; Antibiotics. |
| Record ID: | 1508516 |
| Full text PDF: | http://digitool.library.mcgill.ca/thesisfile68579.pdf |
Abstract
The optical antipode of anhydromyriocin, the (gamma)-lactone derived from the antibiotic myriocin, was synthesized from L-arabinose. The identity of myriocin and thermozymocidin was confirmed, and their relative and absolute stereochemistries were established. In contrast to its natural enantiomer, (-)-ent-anhydromyriocin showed but little antifungal activity.
