AbstractsBiology & Animal Science
Light and electron microscopic studies on the effect of hydrocortisone on the thymus of neonatal ICR/Ha inbred mice
| Institution: | McGill University |
|---|---|
| Department: | Department of Anatomy. |
| Degree: | MS. |
| Year: | 1971 |
| Keywords: | Anatomy. |
| Record ID: | 1489695 |
| Full text PDF: | http://digitool.library.mcgill.ca/thesisfile126812.pdf |
Abstract
The purpose of this experiment was to study cytological changes in the thymus of neonatal mice during hydrocortisone induced involution and regeneration with the light and electron microscopes. Neonatal mice of strain ICR/Ha were used in this study. They were injected subcutaneously with 0.1 mg hydrocortisone within 24 hours after birth. The weights, mitotic indices, and histology of the treated thymuses were compared to the control groups at 6 hours, 24 hours, and 3, 15, and 30 days post-treatment. An analysis of the ratio of the thymic weight to body weight in the treated group showed a significant decrease at 24 hours, and 3 days after treatment.
