AbstractsMedical & Health Science

[...] The experiments to be presented in this thesis have been undertaken with the object of further studying the role played by the adrenal cortex in the protein metabolic changes following stress, as well as other factors which may have an influence upon these changes. The author claims to a "contribution to knowledge" lie in the belief that (1) the data to be presented provide a new interpretation for the changes in urinary nitrogen observed in the rat following adrenalectomy. (2) The data referable to urinary nitrogen changes following fracture lend support to the concept that the adrenal cortical hormone which plays a part in the process is ANTI ANABOLIC in nature. (3) It will be shown that while the adrenal cortical hormones appear to be necessary for the appearance of an increased nitrogen excretion following trauma, they are NOT essential for the mobilization of endogenous 3). protein in the protein depleted rat following food withdrawal, and that this phenomenon is not inhibited by the administration of an anabolic steroid hormone.