An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds
Institution: | University of Cape Town |
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Department: | |
Degree: | MS |
Year: | 2014 |
Keywords: | Medical Biochemistry |
Record ID: | 1475696 |
Full text PDF: | http://uctscholar.uct.ac.za/PDF/175840_Smith_M.pdf |
Includes abstract. Crushed garlic contains organosulfur compounds (OSC), which are reported to have cancer chemotherapeutic properties both in vitro and in vivo. A library of 15 organosulfur analogues were obtained as mechanistic probes in WHCO1 oesophageal cancer cells. Structure-activity studies showed a positive correlation between the anti-proliferative-IC50 of disulfides and the relative stability of their anion leaving groups, as assessed through resonance and quantified by predictive pKa-values.