AbstractsBiology & Animal Science

An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds

by Muneerah Smith

Institution: University of Cape Town
Degree: MS
Year: 2014
Keywords: Medical Biochemistry
Record ID: 1475696
Full text PDF: http://uctscholar.uct.ac.za/PDF/175840_Smith_M.pdf


Includes abstract. Crushed garlic contains organosulfur compounds (OSC), which are reported to have cancer chemotherapeutic properties both in vitro and in vivo. A library of 15 organosulfur analogues were obtained as mechanistic probes in WHCO1 oesophageal cancer cells. Structure-activity studies showed a positive correlation between the anti-proliferative-IC50 of disulfides and the relative stability of their anion leaving groups, as assessed through resonance and quantified by predictive pKa-values.