AbstractsBiology & Animal Science

How Notch and Wnt make T-cells tick

by C. Helbig

Institution: Universiteit van Amsterdam
Year: 2013
Record ID: 1264933
Full text PDF: http://hdl.handle.net/11245/1.385757


This dissertation shows that the ancient Wnt and Notch signaling modules have been coopted by the immune system to direct T-cell responses. Notch has turned out to be particularly dedicated to induction of effector cell differentiation and function. Lack of Notch activation may predispose cells to less terminally differentiated fates, as most prominently suggested by our results on CD8+ T-cells. A more restricted role seems to be played by Wnt, which selectively controls survival of a subset of effector cells. With these studies, we have identified some of the cogwheels and springs that control the inner workings of the immune system.