AbstractsMedical & Health Science

Clinical Relevance of Genetic Alterations in Acute Lymphoblastic Leukemia in Children with Down syndrome

by T.D. Buitenkamp (Trudy)

Institution: Erasmus University
Year: 2014
Keywords: genetics; acute lymphoblastic leukemia; children; Down Syndrome; hematopoiesis; blood cells; hematopoietic stem cells
Record ID: 1260286
Full text PDF: http://hdl.handle.net/1765/51606


abstract__Abstract__ Hematopoiesis encompasses the process by which mature peripheral blood cells are generated by differentiation of hematopoietic stem cells (HSC) in the bone marrow (BM). The daughter cells of HSC’s, progenitor cells, can each commit to the myeloid or lymphoid differentiation pathways that lead to the production of one or more specific types of mature blood cells. These cells are then released in the peripheral blood. The myeloid lineage generates platelets, erythrocytes, granulocytes (basophils, neutrophils and eosinophils) and monocytes, whereas the lymphoid lineage differentiates into T and B-lymphocytes.markdown