AbstractsComputer Science

In silico Medicinal Chemistry: Investigating GPCRs: key regulators of signal transduction and cell function

by A.J. Kooistra




Institution: Vrije Universiteit Amsterdam
Department:
Year: 2015
Keywords: GPCRs; virtual screening; membrane proteins; transmembrane proteins; computer-aided drug design; chemogenomics; functional selectivity; histamine receptor; adrenoceptor; antihistamine; site-directed mutagenesis; structure-affinity relationship; protein-ligand interactions; GPCR crystal structures
Record ID: 1258076
Full text PDF: http://hdl.handle.net/1871/52308


Abstract

Leurs, R. [Promotor] Esch, I.J.P. de [Promotor] Graaf, C. de [Copromotor]