AbstractsBiology & Animal Science
Targeting CD47-SIRPα interactions for potentiating therapeutic antibody-mediated tumor cell destruction by phagocytes
| Institution: | Universiteit van Amsterdam |
|---|---|
| Department: | |
| Year: | 2014 |
| Record ID: | 1255976 |
| Full text PDF: | http://hdl.handle.net/11245/1.418410 |
Abstract
The primary aim of the studies described in this thesis was to investigate the role of CD47-SIRPα interactions in therapeutic antibody-dependent tumor cell destruction by human phagocytes and also explore the killing mechanism(s) by which human phagocytes, and in particular human neutrophils, mediate therapeutic antibody-dependent cytotoxicity towards cancer cells.
