AbstractsBiology & Animal Science

The most important property of a drug delivery system is its ability to deliver the active pharmaceutical ingredient API to the site of action in the body in an amount sufficient to produce the desired therapeutic response This property of the drug delivery system is referred to as bioavailability Bioavailability is more precisely defined as the rate and extent of absorption availability of drug to the systemic circulation About 95percentage of all new potential therapeutics API exhibit low and variable oral bioavailability due to their poor aqueous solubility at physiological pHs and consequent low dissolution rate These drugs are classified as class II drugs under BCS and pose challenging problems in their pharmaceutical product development process The drug in solid dosage form tablet must undergo dissolution before it is available for absorption from gastrointestinal tract Dissolution forms the rate limiting step in the absorption of drugs from solid dosage forms especially when the drug is poorly soluble newline newline newline%%%Reference pgs: 92-100 Summary pgs: 257