AbstractsBiology & Animal Science

The current interest in the creation of large searchable libraries of organic compounds has newlinecaptured an imagination of organic chemist and the drug discovery community,considering the necessity for new and novel chemical inhibitors of biological functions. newlineHere the basic objective to introduce chemical diversity in the molecular frame work of newlinesome heterocyclic compounds, in order to synthesize pharmacologically interesting newlineheterocyclic compounds. Synthesis, Characterization and looking to the application of newlineheterocyclic compounds. newlineIn this thesis we have carried out study to understand; showing an urgent need to newlinediscover new antimalarials, due to the spread of chloroquine resistance and the limited newlinenumber of available drugs. This thesis contains six chapters and brief description as newlinefollows. newlineChapter 1 Introduction newlineMalaria, the most prevalent and most pernicious parasitic disease of humans, is estimated newlineto kill about two million people, mainly children, each year. Several new drugs along newlinewith chloroquine, the first synthetically developed antimalarial drug proved to be a newlinesuccessful cure in the past 50 years. The emergence and spread of resistant parasites to newlinesome of the drugs and their combination has made it virtually ineffective in most parts of newlinethe world. And thus, it is indispensable to discover, design, and develop new drugs with newlinedifferent mechanisms, with diversity in chemical structure and be efficacious against drug newlineresistant strain. In addition to this it should be safe for children and pregnant women, and newlinebe affordable. The ability to treat and control P. falciparum infection through newlinechemotherapy has been compromised by the advent and spread of resistance to newlineantimalarial drugs. newlineABSTRACT newlineSURESH GYAN VIHAR UNIVERSITY, JAIPUR IX newlineChapter 2 Review of Literature newlineThere are several targets validated for development of antimalarial agents. Falcipain is a newlinecysteine protease enzyme, a validated target for malaria. Several studies confirmed the newlineefficacy of cysteine protease inhibitors in arresting and killing para%%%