AbstractsMedical & Health Science

Study of protective effects of stem bark extracts of ficusracemosa in drug induced nephrogenic diabetes insipidus and nephrotoxicity in animal models

by Shivalinge Gowda KP

Institution: Shri Jagdishprasad Jhabarmal Tibarewala University
Department: Pharmaceutical Sciences
Year: 2014
Keywords: Pharmacutical Sciences; Nephrotoxicity; Nephrogenic diabetes insipidus
Record ID: 1186265
Full text PDF: http://shodhganga.inflibnet.ac.in/handle/10603/14584


The objective of this study was to determine nephroprotective effect on gentamicin, cisplatin, cyclosporine induced nephrotoxicity and lithium induced NDI in animal models. The herbal medicines continue to be the mainstay of healthcare systems and source of livelihoods of many communities in India and other countries. This leads to the increased dependence on medicinal products harvested from natural population. This dependence has led to local extinction of some important medicinal plants that include Ficus racemosa. This study has been designed to explore nephroprotective activity of ethanol and aqueous stem bark extracts (EFR and AFR) of Ficus racemosa in gentamicin, cisplatin, cyclosporine induced nephrotoxicity and lithium induced nephrogenic diabetes insipidus in experimental animals. In gentamicin model after adjustment to the local environment, the rats were taken and divided them randomly to six groups (6 rats/ group). Nephrotoxicity was induced with the administration of gentamicin (80mg/kg i.p.) for 8 days to the second group. The EFR and AFR (200 and 400mg/kg. b.w.) were administered to group III, IV, V, and VI respectively by oral route for three days and continued for another 8 days along with gentamicin. The protective effect was estimated by measuring the kidney weight, urine glucose, urine Na+, urine K+, urine volume, urine creatinine, serum urea, serum creatinine, lipid peroxidation, SOD, catalase, GSH and histopathological examination of kidney tissues in rats. newline newlineThere was an insignificant difference in the weight of the isolated kidneys of the gentamicin induced nephrotoxic rats as compared to the normal rat. The gentamicin, EFR/AFR administered rats also showed an insignificant difference in the weights of the isolated kidneys when compared with gentamicin induced nephrotoxic rats.%%%References p. 163-175, List pf publications p. 176