AbstractsMedical & Health Science

Novel strategies in formulation development And evaluation of dispersible tablets;

by Chinmay Anand

Institution: Shri Jagdishprasad Jhabarmal Tibarewala University
Year: 2014
Keywords: Pharmaceutical Sciences
Record ID: 1182948
Full text PDF: http://shodhganga.inflibnet.ac.in/handle/10603/15220


The basic aim behind development of any drug delivery system (DDS) is to achieve a safe and effective therapy for the human being. The dispersible tablet provides a utility dosage form, reducing the need for multiple formulations of the same drug. The novel concept of Rapid dispersible drug delivery system emerged from the desire to provide patient with conventional mean of taking their medication. In recent days major concentration for development work is laid down on the development of organoleptically elegant such as good in taste and patient friendly drug delivery system for the usage of pediatric and geriatric patients. The greater bioavailability of a drug from Rapid dispersible and or dissolving formulations also make it preferable dose as compare to conventional oral dosage forms. newline newlineThe main aim of this study is to develop new concept for the formulation of rapid dispersible tablets or Fast dissolving tablets using novel concepts such as solubility enhancement of active for fast and better release of drug to achieve better bioavailability of active in vivo, taste masking of active with various techniques to improve organoleptic properties and patience compliance. The design of formulation was basically developed for the pediatric and geriatric patients. Paracetamol and Tolfenamic Acid were used as model drugs in formulation study. The present study is an attempt towards application of some novel concepts in formulation of Rapid Dispersible Tablets. On the basis of preformulation study and characterization of active, development of rapid dispersible tablets of Tolfenamic acid initiated with concept of co-micronization with diluents requires. The rapid release of formulation was the basic behind the experimental study. Optimization of formulation parameters was completed to achieve the balance between various physical properties such as disintegration and dispersion time and analytical properties such as release profile of tablets. newline newline%%%