AbstractsWomens Studies

The use of cholesterol lowering medicine for postmenopausal women with estrogen receptor positive breast cancer

by Astrid Helmer Svendsen

Institution: Roskilde University
Year: 2015
Keywords: cholesterol; breast cancer; statin use; estrogenreceptor positive
Record ID: 1120322
Full text PDF: http://rudar.ruc.dk/handle/1800/23330


Cancer is a world-wide problem. One third of cancer cases are breast cancer. Most of the breast cancer cases are in postmenopausal women due to increased estrogen production. Postmenopausal women have an increased risk of developing breast cancer because the estrogen production takes place in the adipose tissue. Furthermore postmenopausal with increased BMI are at greater risk of developing breast cancer due to increased estrogen production in the adipose tissue. Statins are used as treatment of hypercholesterolemia, which more often occurs in postmenopausal women. It is suggested that statins have other effects than preventing hypercholesterolemia. One of these effects is an anticancer effect. This is suggested due to statins influence on different pathways and interme-diates. In this report, the purpose was to investigate whether it could be estimated if statin use re-duces the recurrence risk of breast cancer. Through analyzing different meta-analyses and studies it could be estimated that statins did have a positive effect on breast cancer recurrence but further re-search should be made.