AbstractsBiology & Animal Science

Crowding is synonymous with patchy distributions, where some population units, called patches, contain more individuals than others. Lloyd's mean crowding index is a measure of crowding that has been used in differential equation models in ecology. In this thesis, a new mathematical justification of these models is provided. The models are then adapted for use in infectious disease modelling. Two forms of Lloyd's mean crowding are proposed for use in an infectious disease modelling context - the number of susceptible individuals per infected individual per patch, I*IS, and the number of infected individuals per infected individual per patch, I*. It is shown that the value of I*IS, at the start of an epidemic gives the maximum number of transmission events per patch. Over the course of the epidemic, the value of I* increases towards this limiting value. The ratio of I*IS, and I*, ρI, is therefore proposed as a measure of how efficiently infections are transmitted. As available transmission events reduce with increasing values of I*, disease becomes easier to eliminate and the coexistence of competing infections is facilitated. In response to these results, a vaccination threshold that accounts for patchy distributions of infected individuals is developed, which results in lower proportions of the population needing to be vaccinated when I* increases in value. Human Papillomavirus, a multi-strain sexually transmitted infection with a patchy distribution, is used to explore the implications of these findings in the real world. It is shown that vaccination targeting one strain can result in increases in infection with another, but that a limited degree of cross protection against the non-target strain can eliminate it, in keeping with the fact that patchy distributions make infections easier to eliminate. Finally, the relationship between patch migration and crowding is shown. Changes in migration can either result in crowds of infected individuals and limited spread of infection, or the uniform spread of infection throughout the population. This final result demonstrates that understanding the movement of individuals is critical to controlling epidemics.